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Carcinogenesis 23 , 19792004 (2002)

The risks of NVPs include: 100, 101 unknown long-term health effects intentional and accidental poisoning acute nicotine toxicity, injuries, burns and lung injury dual use with continued smoking 102 greater long-term exposure to nicotine than the use of other smoking cessation measures 103 diversion leading to use by non-smokers acting as a gateway to tobacco use the potential to promote nicotine use and re-normalise smoking among those who do not smoke, especially young people 104 Nicotine exposure can harm adolescent brain development 104 potential medicolegal risks for prescribers

due to FDA regulations

Pop culture perpetuated by Hollywood continued to influence the country

Eur J Drug Metab Pharmacokinet 42:943954 Benowitz NL, Hukkanen J, Jacob P 3rd (2009) Nicotine chemistry, metabolism, kinetics and biomarkers