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The authors concluded by clarifying that a lack of statistical significance is not the same as having no effect

28 Schmid-GrendelmeierP.AltznauerF.FischerB.BizerC.StraumannA.MenzG.et al (2002)

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Further, among adults who formerly and currently smoked, there was no marginal independent association between EC use and respiratory outcomes over and above smoking status, which is consistent with Sargent et al.s conclusion [14] that cigarette smoking largely explains onset of respiratory symptoms, with no additional risk introduced by ECs

It works best when combined with counseling and behavioral therapy in addition to support with friends