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The mechanism may be related to the decreased inflow of iron, TF and TFR1, the upregulation of GPX4, xCT, and FTH1, and the downregulation of ACSL4, MDA and LPO levels

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We observed that the annual eGFR decline in the monotherapy period of SGLT2i or GLP1Ra (2.6 9.9 mL/min/1.73 m 2 /year) was significantly lower after combination therapy (1.2 6.0 mL/min/1.73 m 2 /year) ( p = 0.005)

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For the year ended March 31, 2023, net global sales of Padcev totalled 44.4 billion JPY ($337.75 million USD)

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