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By performing an enrichment analysis for smoking-related phenotypes in the NHGRI-EBI GWAS Catalog, these authors found that these smoking-related methylated genes were significantly overrepresented in all types of cancer (P = 8.0 10 15 ), lung adenocarcinoma (P = 1.5 10 3 ), and colorectal cancer (P = 1.4 10 3 ), which is in line with our findings

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Palmoplantar involvement determines a thickening of the palms and soles of leather-like appearance without true hyperkeratosis (Fig