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In a model of lipopolysaccharide (LPS)-induced visceral hypersensitivity and repeated water avoidance stress (WAS) in rats, liraglutide effectively reduced visceral allodynia by suppressing pro-inflammatory cytokine production and improving colonic barrier integrity [59]

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Common Non-Weight Side Effects: Beyond weight changes, Wellbutrin may cause several other common side effects

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These medications are administered via subcutaneous injection, with dosing gradually increased to minimise gastrointestinal side effects

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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

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The company's approach reflects the growing importance of Canada's regulatory environment as a benchmark for international pharmaceutical approvals

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