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56 The peptide is rapidly degraded by dipeptidyl peptidase-4 into GLP-1 amide and subsequently cleared renally, resulting in a short half-life of approximately two minutes

Sugiyama, Tottori Univ.) Tyrosine is one of the major targets of protein oxidation, and until today various tyrosine derivatives such as nitrotyrosine, dityrosine and halogenated tyrosine depending on the type of free radicals

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The rate of discontinuation due to adverse events varied from 5% to 19%, predominantly due to gastrointestinal side effects [17]

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