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In addition, there were no significant differences in the levels of serum and CSF interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), resistin plasminogen activator inhibitor-1 (PAI-1), tissue necrosis factor- (TNF-), and hepatocyte growth factor (25)

The notion that GLP-1 analogues may affect feeding even when they do not enter the brain is supported by studies showing that large molecular size GLP-1 receptor agonists (albumin-conjugated GLP-1 receptor agonists), that cannot cross the blood-brain barrier can inhibit feeding in both humans and mice

One study reported one rat out of 8 expressing human islet amyloid polypeptide (HIP) as a model for diabetes developed pancreatitis when treated with sitaglyptin for 12 weeks (70)

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