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During wound healing, MMPs play dual roles: they facilitate tissue debridement and cell migration in early healing phases, while excessive or prolonged MMP activity can impair matrix deposition and delay closure

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For example, the combination of 2-deoxyglucose (glycolytic inhibitor), metformin (glycolytic inhibitor), compound C (an AMPK inhibitor), MLN128 (mTOR1 inhibitor), and other glutamine metabolism inhibitors have shown synergistic antitumor effects in some cancer models (Elgogary et al., 2016

Haahtela T, Holgate S, Pawankar R, Akdis CA, Benjaponpitak S, Caraballo L, Demain J, Portnoy J, von Hertzen L, WAO Special Committee on Climate Change and Biodiversity

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