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These processes can affect the bioavailability of the administered (pro)drug or nanocarrier and consequently its delivery to the target site in the brain

Unlike most of the injectable peptides covered above, GHK-Cu has meaningful evidence for topical application its small enough to cross the stratum corneum and reach dermal fibroblasts at relevant concentrations

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In the future, high-quality research needs to be further carried out to clarify its clinical positioning and safety, so as to promote its rational application in digestive system diseases

& Harrison, R