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Talsania, T

Artemisinin activation is decreased in PfK13 mutant lines Artemisinin requires activation by free heme, thus we anticipated that the decrease in heme levels observed in 3-6 hpi ring-stage parasites would result in decreased artemisinin activation and, therefore, decreased activity

Research applications include: Wound Healing and Collagen Biosynthesis induction of ECM gene expression and fibroblast proliferation (Pickart et al., 2015)