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Vitamin B12 deficiency and pernicious anaemia While pernicious anaemia accounts for a high proportion of cases of vitamin B12 deficiency, other causes include malabsorption or an inadequate dietary intake of vitamin B12 (see Table 1)[4,814]

inspect for discolouration or particles (note that B12 solution is normally red) Prepare the injection site common sites include the thigh (vastus lateralis) for both IM and SC injections, or the ventrogluteal area for IM administration if trained to use this site Administration technique: Clean the injection site with an alcohol wipe and allow to dry completely

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Informed, written consent was provided by all participants or their surrogates before trial commencement