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There is no absolute medical contraindication between alcohol and semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound), and the FDA prescribing information does not require complete abstinence

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Therefore, identifying the structural determinants of the ligand-stimulated GSH transport in MRP1, and evaluating its relationship with the basal transport of GSH and the transport of the drug, constitutes one central yet unknown cornerstone to be able to propose MRP1-mediated CS as an anti-cancer therapy