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4.1 Inflammation and endothelial dysfunction Chronic systemic inflammation is a hallmark of many immune-mediated skin diseases and is considered the main driving factor of endothelial dysfunction (50, 51), while endothelial dysfunction underlies the pathophysiology of ED (52, 53)

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Both oxidatively modified SOD1 and UCH-L1 are involved in the formation of cytoplasmic inclusions in ALS mouse models and in ALS patients [113]