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(6) Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, et al (2020) FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging (Albany NY)

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However, despite their significant quality of life improvements, they can be accompanied by significant gastrointestinal side effects, including nausea, vomiting, abdominal pain, diarrhea, fatigue, and weight loss 16

But it does not directly help with weight loss rather it gives you sufficient energy to motivate you into doing more exercise and working out