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It should be avoided in patients with severe gastrointestinal disorders such as gastroparesis, as delayed gastric emptying may worsen symptoms[13]

Yamada Y, Katagiri H, Hamamoto Y et al (2020) Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial

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The rate and extent of regain vary significantly based on genetic factors, lifestyle adherence, and how aggressively you maintain behavioral modifications

[1] However, the combination may present practical considerations rather than pharmacological contraindications