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In conclusion, we describe a novel additive effect on vitamin B 12 deficiency risk for metformin exposure with a previously reported genetic risk factor in the cubilin receptor gene

54 A nationwide cohort study of 120,054 patients with type 2 diabetes over a median follow up of 7.4 years found an 11% reduction in the rate of dementia with GLP-1 receptor agonists (95% of patients were on liraglutide) when used as a second-line treatment compared with other glucose-lowering therapies, with greater benefit seen with longer duration of use

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We thought that removing glucagon would impair insulin secretion by disrupting alpha-to-beta cell signaling, Campbell said