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333 Similarly, aggregation-prone proteins, including mutant huntingtin (Htt) and Ataxin-3, disrupt the autophagy machinery in HD and spinocerebellar ataxias, linking impaired autophagy directly to disease progression
You must seek medical attention and contact your practitioner if you develop any signs or symptoms of skin infection around the injection site
355 However, due to our lack of understanding of exosome biology, structure, and biogenesis, the strategy of endogenous drug loading still requires further research and optimization
Generation of knockout, knockdown and cDNA overexpression cell lines sgRNAs (oligonucleotide sequences are indicated below) were cloned into lentiCRISPR-v2 (Addgene) (for GCLC )or into lentiCRISPR-v1 (Addgene) (for SLC25A39 ) linearized with BsmBI by T4 ligase (NEB)
