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The software package R (Version 3.2.3, obtained from the R Foundation: was used for data file processing and analysis

Intensive Blood-Glucose Control With Sulphonylureas or Insulin Compared With Conventional Treatment and Risk of Complications in Patients With Type 2 Diabetes (UKPDS 33)

Weighing Cost Against Health Benefits Studies suggest that Semaglutide could potentially reduce the risk of adverse cardiovascular events such as stroke and heart attack by 20% in obese individuals with a history of cardiovascular disease

Some patients may respond more favorably to semaglutide or struggle with tirzepatides side effects

The prespecified bioequivalence criteria according to EMA, FDA and PMDA guidelines were met across the three investigated dose levels of 2G versus 1G oral semaglutide (9 mg vs 14 mg, 4 mg vs 7 mg, 1.5 mg vs 3 mg) (Table 2)