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The formulation originated in weight-loss clinics in the 1990s as an adjunct to calorie-restricted diets

Under homeostatic conditions, the deubiquitinase PSMD14 cleaves K27-linked polyubiquitin chains at K313 of IRF3, thereby preventing autophagic recognition and degradation (193)

They are located in the space of Disse and maintain close interactions with sinusoidal endothelial cells and hepatocytes

This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring

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