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Jastreboff, A.M., et al., Tirzepatide Once Weekly for the Treatment of Obesity

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doi: 10.1016/S2213-8587(22)00349-7 13 LiSVandvikPOLytvynLGuyattGHPalmerSCRodriguez-GutierrezRet al

Structural Comparison with Tirzepatide# The structural relationship between retatrutide and tirzepatide warrants detailed comparison, as both are multi-receptor incretin agonists developed by Eli Lilly: The most pharmacologically consequential structural difference is the engineering of glucagon receptor agonism into retatrutide