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In the Phase III MARCH trial, which enrolled 93 patients across several different genetic subtypes of PFIC, Livmarli significantly improved pruritus symptoms in treated patients, as well as concentrations of serum bile acids and bilirubin

However, when combined with insulin or sulphonylureas, the risk increases significantly

How often should I test my thyroid while on a weight loss injection

Which is better for heart health

In that situation, your healthcare provider may consider spironolactone as one part of a broader plan, especially if your hair loss looks more like female-pattern hair loss than diffuse thyroid shedding. A practical way to think about it is this: thyroid treatment supports the whole system, while spironolactone may help if androgens are acting like an extra brake on hair follicles or skin