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Poria cocos acidic polysaccharides (PCAP) significantly reduced the mRNA and protein expression levels of NLRP3, ASC, caspase-1, IL-1, and IL-18 in the prefrontal cortex of rats in a chronic unpredictable stress model ( Gastrodia elata polysaccharides (GEP) exhibited the ability to attenuate the relative mRNA expression of pro-inflammatory cytokines TNF- and IL-1 in hippocampal tissues of depressed mice, thereby exerting a neuroprotective effect and ameliorating LPS-induced depressive-like behaviors in mice ( Momordica charantia polysaccharides (MCP, 200 and 400 mg/kg) also decreased hippocampal levels of IL-1, IL-6, and TNF-, alleviating depressive behaviors in mice subjected to chronic social frustration stress ( The intervention of Astragalus polysaccharide (APS) significantly reduced the levels of hippocampal TNF-, IL-1, and IL-6 in rats with CUS-induced depression (Wang et al., 2018
L-ascorbic acid (the most potent form of topical vitamin C) requires a low pH, typically around 2.5 to 3.5, to remain stable and penetrate the skin
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(1) S Sayeed Ahmad, K Ahmad, E Ju Lee, Y-H Lee, and I Choi (2020) Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases Cells, 2020 Jul 24, Volume 9 (Issue 8), Page 1773
