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In later stages of pregnancy, SHS may induce oxidative stress and inflammatory responses that compromise maternal-fetal immune interactions and inhibit immune tolerance at the maternal-fetal interface 11,12

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Clinical and experimental data suggest that platelets and the coagulation system also play an important role in atherogenesis and atherothrombosis, and that exposure to cigarette smoke has prothrombotic effects by impairing the functions of endothelial cells, platelets, fibrinolytic factors, and coagulation factors (Oakes et al., 2018)