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A clinical pilot study

-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

The concomitant administration of -tocotrienol has demonstrated an increased efficacy of gemcitabine (88), and a phase I study on pancreatic cancer patients was conducted with escalating doses of -tocotrienol in the 2 weeks before surgery (91)

This pattern is significant because it imitates the physiological pulsatility of the growth hormone axis rather than producing a persistently elevated level

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