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Laboratory studies show that activating these receptors reduces anxiety-like behaviors in test animals and produces antidepressant effects comparable to established psychiatric medications

Eur Rev Med Pharmacol Sci 25:6773 Nelson T, Zhang LX, Guo H, Nacul L, Song X (2021) Brainstem abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: a scoping review and evaluation of magnetic resonance imaging findings

Although extremely powerful, these methods present several challenges

Patients who discontinued tirzepatide due to planned pregnancy should inform their obstetric provider, as the medication should be stopped at least 1 month before a planned conception according to FDA labeling

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