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Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses

After SS-31: extended cognitive stamina across the full working day, less pronounced mental fatigue under sustained cognitive demand, clarity that does not degrade as sharply under physical fatigue

Similarly, in a letter to the committee, the Alliance for Pharmacy Compounding urged the FDA to address safety concerns through targeted safeguards rather than outright restrictions

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doi: 10.1208/s12249-017-0844-8