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Injectable GLP-1s like Zepbound produce slightly higher weight reduction in head-to-head trials, but many people discontinue weekly injections because the routine becomes burdensome

The previous reports of multiple beneficial effects of orally administered d-allulose prompted us to infer that it might act through stimulating GLP-1 release and/or vagal afferent signaling, both of which transmit gut signals to remote organs including the brain

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