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This is a universal principle in pharmacology: combination therapy with lower individual doses often produces better outcomes with fewer adverse effects than high-dose monotherapy

This work is partly funded by the German Research Foundation (DFG) to A.Y.R

The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C gamma in immature rats

Lixisenatide is structurally related to exendin-4 (six lysine residues have been added to the C terminus, and one proline in the C-terminal region has been deleted) but can be administered once daily (QD)

Recently, administration of a long-acting GIP receptor agonist in humans, reduced GLP-1 analogue related gastrointestinal side effects, including nausea and vomiting (106)