gsh reduced glutathione 90c Oxidation-reduction pathway of reduced glutathione

The use of single cell RNA-sequencing technology to detect the enrichment of ferroptosis-related genes has led to more rapid and accurate detection of ferroptosis

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Glutathione is crucial for the proper functioning of these mitochondria helping to protect them from oxidative damage and ensuring efficient energy production

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GPx1 deficiency was found to promote mitochondrial dysfunction in response to stress, such as I/R and doxorubicin exposure in cardiomyocytes and in trauma models in brain, whereas GPx1 overexpression limited the mitochondrial respiratory stress [41, 43, 44, 114]