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Neuroprotection Research: Emerging gut-brain axis investigations: pro-inflammatory cytokine reduction in hippocampus, neuronal integrity preservation after trauma, dopaminergic and serotonergic system interactions, behavioral studies in rodent models

Consistently, knockout of LPCAT3 in lung epithelial cells conferred resistance to ferroptosis induced by the Ras-selective lethal compound 3 (RSL3), and reduced expression of ACSL4 or LPCAT3 diminished the availability of peroxidizable phospholipid substrates [39], thereby inhibiting ferroptosis and further emphasizing the critical role of PUFA metabolism in ferroptosis

Gut microbes 5 , 458467 (2014)