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doi: 10.1007/s00109-018-1645-6 77 YennemadiASKeaneJLeischingG

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Inducers of CYP3A4 The concomitant use of hydrocodone bitartrate and acetaminophen tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of hydrocodone (see CLINICAL PHARMACOLOGY), resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to hydrocodone (see WARNINGS)

During the wrapping stage, this synergy boosts the delivery of active ingredients for greater effectiveness