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GHK-Cu (glycyl-L-histidyl-L-lysine bound to copper(II)) has been used for decades in low-concentration topical cosmetics with a generally favorable tolerability record, but there is almost no published human adverse-event data especially for injectable or systemic research use

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But things were, but it was handled different in the two tissues

Chen Y-H, Yang S-F, Yang C-K, Tsai H-D, Chen T-H, Chou M, Hsiao Y-H (2021) Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells

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