Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK
The FDA cited insufficient human safety data, potential for immune reactions, and manufacturing impurity concerns as the bases for this classification
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Biologically independent duplicate experiments were performed and imaged
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