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doi:10.1016/j.drugpo.2015.04.003

It is worth emphasizing that the gradual approach used did not reduce weight loss or compromise glycemic efficacy, reinforcing that tolerability, not symptom intensity, should guide dose advancement ( A patient centered approach of starting low and going slow prioritizes safety and adherence, building on the principle of doing no harm

Weeks of no progress on the scale, after experiencing the dopamine hit of consistent losses, can trigger frustration, self-doubt, disordered eating behaviors, and the temptation to make drastic changes that often backfire

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