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Collectively, the data from 20 healthy nonobese subjects indicated that elevated colonic propionate production diminished striatal blood oxygen level-dependent signals, especially in reaction to high-energy foods, indicating that propionate mitigates reward-driven eating behavior through striatal pathways, irrespective of alterations in plasma PYY, GLP-1, glucose, or insulin levels

One 2024 study in Cell Metabolism showed that a single low dose of GLP-1 reduces inflammation, independent of weight loss

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[DOI] [PubMed] [Google Scholar] 70.Caruso U., Leone L., Cravotto E., Nava D

American Diabetes Association (2004) Pancreas transplantation in type 1 diabetes