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Upon activation, mast cells rapidly release pruritogenic mediators such as histamine, prostaglandin D 2 (PGD 2 ), tryptase, and -hexosaminidase (Poto et al., 2022), which collectively stimulate C-type sensory nerve fibers and trigger neuroimmune amplification (Siiskonen and Harvima, 2019)

These liposomes demonstrated a synergistic antioxidant activity that was greater than the sum of the individual effects of each active ingredient

Omega-3 fatty acids may positively affect human health in several ways

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Together, these effects have been documented in experimental systems to modify gene expression patterns in ways that reduce chronic inflammatory signaling and support transitions toward tissue stabilization