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[2] This increase in MMP-2 was also accompanied by a rise in MMP-2 mRNA levels, indicating that GHK-Cu potentially enhances MMP-2 expression at the transcriptional level

The soluble form, consisting of 727 aa, lacks the transmembrane and intracellular domains and is found in serum, bile, saliva, and other bodily fluids (66)

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Autophagy is divided into macroautophagy (usually called autophagy), microautophagy, and molecular chaperone-mediated autophagy (Jiang and Mizushima, 2013), which generally refers to macroautophagy