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(2022) observed that although a two-month synbiotic intervention consisting of 510 9 CFU Lactobacillus acidophilus and Bifidobacterium longum and 60 mg of FOS in a double-blinded randomized controlled clinical trial involving hemodialysis patients with gastrointestinal complaints had a substantial effect in improving constipation and general quality of life in the synbiotic group, it did not reduce the levels of IS in their serum compared to the placebo group

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Additionally, there is nuclear factor-B-dependent upregulation of inflammatory genes, such as cyclooxygenase and inducible nitric oxide synthase, in astrocytes

Therefore, combining glutathione with other markers that reflects various dysregulated molecular pathways, such as vitamin D, would likely result in a better approach for the early diagnosis of ASD