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It is a recombinant form of the peptide exendin-4, which is a GLP-1 receptor agonist with a 53% similarity to the gastrointestinal hormone GLP-1 and it is resistant to DPP-4 inactivation with a 140-minute half-life after subcutaneous administration allowing therapy by a twice daily administration [36]
Achn Buil, B., Tackenberg, C., Rust, R., 2023
Retatrutide has been tested at up to 12 mg weekly in Phase 2 and Phase 3 trials
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