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That dissociation is the strongest practical argument for treating cerebrospinal fluid and plasma markers in these trials as exploratory readouts of target engagement rather than as stand-ins for benefit

SLC22A12 gene encoding for the urate transporter hURAT1 defects leads to primary renal hypouricemia characterized by increased UA excretion from a reduced reabsorption (Tana et al., 2018)

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The efficacy of a subcutaneous injection of soluble Vitamin B12 in lambs

Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson's disease brains