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Incretin analogues are an increasingly important class of drugs that provide substantial health benefits for people with obesity, with adverse effects limited primarily to gastrointestinal disturbances

Therefore, there is little data on any long-term side effects of taking semaglutide

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As next generation efforts attempt to develop novel non-peptide, orally available molecules for these GPCRs, new animal models expressing human receptor orthologs may be required because small molecule ligands make fewer receptor contacts, and thus, the impact of amino acid differences across species may be substantially greater

Orlistat and Alli can cause oily stools, urgency, gas, and digestive discomfort, especially after higher-fat meals