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Activated microglia produced inflammatory mediators, such as prostaglandin E 2 , interleukin-1 TNF, ROS (peroxideH 2 O 2 , superoxideO 2 ), and reactive species nitrogenous (RNS: NO

This triggers an influx of Ca 2+ into the cell, which in turn activates Ca 2+ -sensitive enzymes, such as adenylate cyclase

Because omeprazole affects how the stomach digests and absorbs substances, it can potentially interfere with how other medications are absorbed

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