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Without controlled human studies, any dosing discussion is speculative and should be considered unsafe outside research settings

Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section

Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136

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