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NAC treatment, however, resulted in partial recovery of the apoptotic markers described above suggesting partial protection from the deleterious effects of the drug

While cardiac and smooth muscles tend to be spared in most patients, myocardial degenerative lesions have been reported in thyrotoxicosis, with foci of cell necrosis, mononuclear infiltrates, and mucopolysaccharide deposits similar to those described in extraocular and skeletal muscles (290)

The drug part of a class of medicines known as JAK inhibitors is the first approved treatment in the United States for the condition, which affects more than 300,000 people in the country each year, according to the FDA

Its approximately 24-hour half-life supports once-daily administration, making it convenient for sustained study protocols