Lead author, Luis-Emilio Garca-Prez, MD, PhD, MBA, explained the key findings to Medical News Today : This was a post-hoc sub-group data analysis of the SURMOUNT-1, SURMOUNT-2, SURMOUNT-3 and SURMOUNT-4 phase 3 trials that showed tirzepatide injections (5 mg, 10 mg, 15 mg) significantly reduced body weight compared to placebo regardless of sex, with greater body weight reduction associated with tirzepatide in females compared to males. Luis-Emilio Garca-Prez, MD While the SM-1 and SM-2 trials involved randomization immediately after a screening period, SM-3 had a 12-week lead-in phase with intensive lifestyle changes, and SM-4 had a 36-week lead-in with open-label tripeptide treatment
The correct combination varies based on skin type, age, and individual objectives
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2018;65(5):e26911