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Blood pressure improvements were equally striking, with 41% of participants on 8mg doses discontinuing at least one antihypertensive medication by study completion

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Effect of JNJ-42165279 on anandamide levels Plasma concentrations of JNJ-42165279 correlated strongly with AEA levels at the corresponding time point (r s [133] = 0.67, p 5% of participants in any treatment arm are reported in Supplementary Table S7 (for all AEs see Supplementary Tables S8)