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In particular, single-method workflows often favor specific chemotypes or receptor states, potentially limiting scaffold diversity and reducing enrichment efficiency

Natural polyphenols, widely used in the functional food industry, have been shown to protect against CVD, DM, and HTN by inhibiting key enzymes like ACE, -glucosidase, and -amylase, increasing NO levels, and improving EF (373)

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for example, coronary heart disease, or in those that have a BMI lower than 35kg/m 2 and for whom insulin therapy would have significant occupational implications[15]

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