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When semaglutide activates GLP-1 receptors in the hypothalamus, it tells your brain you are full, even when your stomach is not

Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

Many patients find their appetite naturally drops, which makes a balanced diet easier to sustain

And the label states that tolerance to the appetite-suppressing effect usually develops within a few weeks, at which point the drug should be discontinued rather than escalated

8.2 The Specialty Pharmacy Channel Most specialty drugs are not dispensed through retail pharmacies