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Furthermore, GLP-1 plays a protective role in cardiac microvasculature in diabetes by preventing apoptosis, oxidative stress, and microvascular dysfunction

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However, if the portal vein system is evolutionarily developed for peripheral-central communications, including sending the signal to the brain for native GLP-1 to exert its anorexic and other brain functions, this existing system likely also mediates the pharmacological function of various GLP-1RAs