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The ratio of membrane versus cytosolic IGF-1R localization in the untreated panel indicates cytosolic retention of hyposialylated IGF-1R in GNE knockdown cells but not in V603L GNE mutant cells

It also helps preserve lean muscle, which becomes increasingly important during perimenopause and menopause as muscle naturally declines with age

Metabolic Support: More muscle means a higher resting metabolic rate, aiding long-term fat-loss maintenance

Its these real-world outcomesnot just clinical studiesthat highlight the impact of making semaglutide treatment accessible, especially for those previously left out of the conversation

386 :q1645 doi:10.1136/bmj.q1645